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Assay Detail

CHEMBL1964046

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay. (Class of assay: confirmatory)
ChEMBL ↗
124
Total Activities
124
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitochondrial import inner membrane translocase subunit TIM23 (CHEMBL1741180) ↗
Type SINGLE PROTEIN
Organism Saccharomyces cerevisiae S288c

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 124 4.82 6.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1309497 — — 1 6.34
CHEMBL2003655 — — 1 6.24
CHEMBL1992176 — — 1 6.21
CHEMBL1985130 — — 1 6.10
CHEMBL1323644 — — 1 6.05
CHEMBL1525481 — — 1 6.05
CHEMBL1709744 — — 1 6.01
CHEMBL1571839 — — 1 5.97
CHEMBL1969207 — — 1 5.85
CHEMBL1993943 — — 1 5.83
CHEMBL2006714 — — 1 5.83
CHEMBL2006017 — — 1 5.82
CHEMBL1993276 — — 1 5.80
CHEMBL1520311 — — 1 5.76
CHEMBL1363112 — — 1 5.76
CHEMBL1966622 — — 1 5.64
CHEMBL2001041 — — 1 5.62
CHEMBL1392335 — — 1 5.61
CHEMBL2001815 — — 1 5.58
CHEMBL246655 — — 1 5.54
CHEMBL1565806 — — 1 5.52
CHEMBL1987661 — — 1 5.43
CHEMBL1608436 — — 1 5.43
CHEMBL2003811 — — 1 5.34
CHEMBL1505528 — — 1 5.16
CHEMBL1536479 — — 1 4.95
CHEMBL1327501 — — 1 4.92
CHEMBL1579264 — — 1 4.89
CHEMBL1985704 — — 1 4.83
CHEMBL1700836 — — 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1309497 — IC50 = 459.0 nM 6.34
CHEMBL2003655 — IC50 = 570.0 nM 6.24
CHEMBL1992176 — IC50 = 617.0 nM 6.21
CHEMBL1985130 — IC50 = 787.0 nM 6.10
CHEMBL1323644 — IC50 = 897.0 nM 6.05
CHEMBL1525481 — IC50 = 882.0 nM 6.05
CHEMBL1709744 — IC50 = 987.0 nM 6.01
CHEMBL1571839 — IC50 = 1060.0 nM 5.97
CHEMBL1969207 — IC50 = 1420.0 nM 5.85
CHEMBL1993943 — IC50 = 1480.0 nM 5.83
CHEMBL2006714 — IC50 = 1480.0 nM 5.83
CHEMBL2006017 — IC50 = 1520.0 nM 5.82
CHEMBL1993276 — IC50 = 1570.0 nM 5.80
CHEMBL1363112 — IC50 = 1750.0 nM 5.76
CHEMBL1520311 — IC50 = 1720.0 nM 5.76
CHEMBL1966622 — IC50 = 2300.0 nM 5.64
CHEMBL2001041 — IC50 = 2370.0 nM 5.62
CHEMBL1392335 — IC50 = 2440.0 nM 5.61
CHEMBL2001815 — IC50 = 2650.0 nM 5.58
CHEMBL246655 — IC50 = 2900.0 nM 5.54
CHEMBL1565806 — IC50 = 3020.0 nM 5.52
CHEMBL1987661 — IC50 = 3690.0 nM 5.43
CHEMBL1608436 — IC50 = 3690.0 nM 5.43
CHEMBL2003811 — IC50 = 4540.0 nM 5.34
CHEMBL1505528 — IC50 = 6870.0 nM 5.16
CHEMBL1536479 — IC50 = 11200.0 nM 4.95
CHEMBL1327501 — IC50 = 12000.0 nM 4.92
CHEMBL1579264 — IC50 = 13000.0 nM 4.89
CHEMBL1985704 — IC50 = 14800.0 nM 4.83
CHEMBL1973048 — IC50 = 15900.0 nM 4.80
CHEMBL1700836 — IC50 = 16000.0 nM 4.80
CHEMBL1311971 — IC50 = 16300.0 nM 4.79
CHEMBL1305910 — IC50 = 16500.0 nM 4.78
CHEMBL1528822 — IC50 = 17300.0 nM 4.76
CHEMBL1594483 — IC50 = 18100.0 nM 4.74
CHEMBL1977950 — IC50 = 19100.0 nM 4.72
CHEMBL1500169 — IC50 = 21600.0 nM 4.67
CHEMBL1976967 — IC50 = 29600.0 nM 4.53
CHEMBL1533040 — IC50 = 33360.0 nM 4.48
CHEMBL1989549 — IC50 = 33220.0 nM 4.48
CHEMBL1992722 — IC50 = 33380.0 nM 4.48
CHEMBL1581799 — IC50 = 34220.0 nM 4.47
CHEMBL2002071 — IC50 = 34140.0 nM 4.47
CHEMBL1993130 — IC50 = 33630.0 nM 4.47
CHEMBL1967430 — IC50 = 42800.0 nM 4.37
CHEMBL1990867 — IC50 = 44300.0 nM 4.35
CHEMBL1966161 — IC50 = 44230.0 nM 4.35
CHEMBL1981206 — IC50 = 46000.0 nM 4.34
CHEMBL1992480 — IC50 = 48370.0 nM 4.32
CHEMBL1973984 — IC50 = 48030.0 nM 4.32