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Assay Detail

CHEMBL1964117

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPK14
ChEMBL ↗
333
Total Activities
322
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 14 (CHEMBL260) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 333 5.99 9.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1991678 — — 1 9.90
CHEMBL1990496 — — 1 9.60
CHEMBL2005792 — — 1 9.30
CHEMBL1984842 — — 1 8.80
CHEMBL1996500 — — 1 8.50
CHEMBL49120 PD-0166285 1.0 1 8.50
CHEMBL119385 NEFLAMAPIMOD 2.0 1 8.30
CHEMBL278041 SB-202190 — 1 8.30
CHEMBL103667 DORAMAPIMOD 2.0 1 8.10
CHEMBL574738 AST-487 1.0 1 8.00
CHEMBL1336 SORAFENIB 4.0 1 7.80
CHEMBL10 SB-203580 — 1 7.70
CHEMBL5416410 DASATINIB 4.0 1 7.50
CHEMBL1970290 — — 1 7.10
CHEMBL2005699 — — 1 7.10
CHEMBL1997892 — — 1 7.00
CHEMBL1964902 — — 1 7.00
CHEMBL1964948 — — 1 6.90
CHEMBL2004637 — — 1 6.80
CHEMBL1998680 — — 1 6.80
CHEMBL1972220 — — 1 6.70
CHEMBL1988581 — — 1 6.70
CHEMBL1994977 — — 1 6.60
CHEMBL1977634 — — 1 6.60
CHEMBL1999506 — — 1 6.60
CHEMBL1978271 — — 1 6.50
CHEMBL253969 OSI-632 2.0 1 6.50
CHEMBL2003689 — — 1 6.50
CHEMBL1974998 — — 1 6.50
CHEMBL2004438 — — 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1991678 — Ki = 0.1259 nM 9.90
CHEMBL1990496 — Ki = 0.2512 nM 9.60
CHEMBL2005792 — Ki = 0.5012 nM 9.30
CHEMBL1984842 — Ki = 1.585 nM 8.80
CHEMBL1996500 — Ki = 3.162 nM 8.50
CHEMBL49120 PD-0166285 Ki = 3.162 nM 8.50
CHEMBL119385 NEFLAMAPIMOD Ki = 5.012 nM 8.30
CHEMBL278041 SB-202190 Ki = 5.012 nM 8.30
CHEMBL103667 DORAMAPIMOD Ki = 7.943 nM 8.10
CHEMBL574738 AST-487 Ki = 10.0 nM 8.00
CHEMBL1336 SORAFENIB Ki = 15.85 nM 7.80
CHEMBL10 SB-203580 Ki = 19.95 nM 7.70
CHEMBL5416410 DASATINIB Ki = 31.62 nM 7.50
CHEMBL2005699 — Ki = 79.43 nM 7.10
CHEMBL1970290 — Ki = 79.43 nM 7.10
CHEMBL1997892 — Ki = 100.0 nM 7.00
CHEMBL1964902 — Ki = 100.0 nM 7.00
CHEMBL1964948 — Ki = 125.89 nM 6.90
CHEMBL1998680 — Ki = 158.49 nM 6.80
CHEMBL2004637 — Ki = 158.49 nM 6.80
CHEMBL1972220 — Ki = 199.53 nM 6.70
CHEMBL1988581 — Ki = 199.53 nM 6.70
CHEMBL1999506 — Ki = 251.19 nM 6.60
CHEMBL1994977 — Ki = 251.19 nM 6.60
CHEMBL1977634 — Ki = 251.19 nM 6.60
CHEMBL1974998 — Ki = 316.23 nM 6.50
CHEMBL2003689 — Ki = 316.23 nM 6.50
CHEMBL1978271 — Ki = 316.23 nM 6.50
CHEMBL2004438 — Ki = 316.23 nM 6.50
CHEMBL1994318 — Ki = 316.23 nM 6.50
CHEMBL253969 OSI-632 Ki = 316.23 nM 6.50
CHEMBL1991377 — Ki = 398.11 nM 6.40
CHEMBL1971223 — Ki = 398.11 nM 6.40
CHEMBL1986899 — Ki = 398.11 nM 6.40
CHEMBL2002660 — Ki = 398.11 nM 6.40
CHEMBL2007073 — Ki = 398.11 nM 6.40
CHEMBL1971223 — Ki = 501.19 nM 6.30
CHEMBL406845 — Ki = 501.19 nM 6.30
CHEMBL1983640 — Ki = 501.19 nM 6.30
CHEMBL939 GEFITINIB Ki = 501.19 nM 6.30
CHEMBL1997335 — Ki = 501.19 nM 6.30
CHEMBL939 GEFITINIB Ki = 501.19 nM 6.30
CHEMBL1980407 — Ki = 630.96 nM 6.20
CHEMBL1991734 — Ki = 630.96 nM 6.20
CHEMBL1992334 — Ki = 630.96 nM 6.20
CHEMBL2006149 — Ki = 630.96 nM 6.20
CHEMBL1993634 — Ki = 630.96 nM 6.20
CHEMBL1998765 — Ki = 630.96 nM 6.20
CHEMBL1983715 — Ki = 630.96 nM 6.20
CHEMBL1975923 — Ki = 630.96 nM 6.20