Assay Detail
Binding
CHEMBL2013352
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Inhibition of Aurora B kinase
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.15 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011940 | — | — | 1 | 8.40 |
| CHEMBL2011934 | — | — | 1 | 8.15 |
| CHEMBL2011941 | — | — | 1 | 7.89 |
| CHEMBL2011935 | — | — | 1 | 7.80 |
| CHEMBL2011928 | — | — | 1 | 7.62 |
| CHEMBL2011931 | — | — | 1 | 7.60 |
| CHEMBL2011932 | — | — | 1 | 7.54 |
| CHEMBL2011929 | — | — | 1 | 7.52 |
| CHEMBL2011927 | — | — | 1 | 7.51 |
| CHEMBL2011933 | — | — | 1 | 7.42 |
| CHEMBL2011926 | — | — | 1 | 7.37 |
| CHEMBL2011930 | — | — | 1 | 7.09 |
| CHEMBL2011936 | — | — | 1 | 7.03 |
| CHEMBL2011945 | — | — | 1 | 6.43 |
| CHEMBL2011942 | — | — | 1 | 6.32 |
| CHEMBL2010815 | — | — | 1 | 6.18 |
| CHEMBL2011937 | — | — | 1 | 6.13 |
| CHEMBL2011944 | — | — | 1 | 6.06 |
| CHEMBL2011943 | — | — | 1 | 5.80 |
| CHEMBL2011939 | — | — | 1 | - |
| CHEMBL2011938 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011940 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2011934 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2011941 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2011935 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2011928 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2011931 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2011932 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2011929 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2011927 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2011933 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2011926 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2011930 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2011936 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2011945 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2011942 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL2010815 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL2011937 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL2011944 | — | IC50 | = | 872.0 | nM | 6.06 |
| CHEMBL2011943 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2011939 | — | IC50 | - | — | - | |
| CHEMBL2011938 | — | IC50 | - | — | - |