Assay Detail
Binding
CHEMBL2013354
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Inhibition of Ikkepsilon using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (CHEMBL3529) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 6.70 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011940 | — | — | 1 | 8.40 |
| CHEMBL2011932 | — | — | 1 | 8.30 |
| CHEMBL2011942 | — | — | 1 | 8.05 |
| CHEMBL2011941 | — | — | 1 | 7.77 |
| CHEMBL2011934 | — | — | 1 | 7.70 |
| CHEMBL2011933 | — | — | 1 | 7.68 |
| CHEMBL2011935 | — | — | 1 | 7.34 |
| CHEMBL2011943 | — | — | 1 | 7.34 |
| CHEMBL2011930 | — | — | 1 | 7.22 |
| CHEMBL2011936 | — | — | 1 | 7.12 |
| CHEMBL2011929 | — | — | 1 | 7.08 |
| CHEMBL2011910 | — | — | 1 | 7.03 |
| CHEMBL2011944 | — | — | 1 | 6.99 |
| CHEMBL2011931 | — | — | 1 | 6.94 |
| CHEMBL2011912 | — | — | 1 | 6.92 |
| CHEMBL2011945 | — | — | 1 | 6.91 |
| CHEMBL2011927 | — | — | 1 | 6.76 |
| CHEMBL2010815 | — | — | 1 | 6.69 |
| CHEMBL2011926 | — | — | 1 | 6.58 |
| CHEMBL2011938 | — | — | 1 | 6.56 |
| CHEMBL2011911 | — | — | 1 | 6.37 |
| CHEMBL2011920 | — | — | 1 | 6.29 |
| CHEMBL2011899 | — | — | 1 | 6.28 |
| CHEMBL2011939 | — | — | 1 | 6.27 |
| CHEMBL2011928 | — | — | 1 | 6.26 |
| CHEMBL2011907 | — | — | 1 | 6.23 |
| CHEMBL2011919 | — | — | 1 | 6.20 |
| CHEMBL2011895 | — | — | 1 | 6.15 |
| CHEMBL2011922 | — | — | 1 | 5.61 |
| CHEMBL2011900 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011940 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2011932 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2011942 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2011941 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2011934 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2011933 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2011935 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2011943 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2011930 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2011936 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2011929 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2011910 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2011944 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2011931 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2011912 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2011945 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL2011927 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL2010815 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL2011926 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL2011938 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL2011911 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL2011920 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2011899 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL2011939 | — | IC50 | = | 541.0 | nM | 6.27 |
| CHEMBL2011928 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL2011907 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2011919 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL2011895 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL2011922 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL2011900 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL2011914 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL2011937 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL2011924 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL2011917 | — | IC50 | - | — | - | |
| CHEMBL2011916 | — | IC50 | - | — | - | |
| CHEMBL2011915 | — | IC50 | - | — | - | |
| CHEMBL2011913 | — | IC50 | - | — | - | |
| CHEMBL2011909 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2011908 | — | IC50 | - | — | - | |
| CHEMBL2011925 | — | IC50 | - | — | - | |
| CHEMBL2011905 | — | IC50 | - | — | - | |
| CHEMBL2011904 | — | IC50 | - | — | - | |
| CHEMBL2011903 | — | IC50 | - | — | - | |
| CHEMBL2011902 | — | IC50 | - | — | - | |
| CHEMBL2011901 | — | IC50 | - | — | - | |
| CHEMBL2011898 | — | IC50 | - | — | - | |
| CHEMBL2011897 | — | IC50 | - | — | - | |
| CHEMBL2011896 | — | IC50 | - | — | - | |
| CHEMBL2011906 | — | IC50 | - | — | - | |
| CHEMBL2011921 | — | IC50 | - | — | - |