Assay Detail
Binding
CHEMBL2013355
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Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TBK1 (CHEMBL5408) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 6.95 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011940 | — | — | 1 | 8.52 |
| CHEMBL2011932 | — | — | 1 | 8.40 |
| CHEMBL2011933 | — | — | 1 | 8.40 |
| CHEMBL2011942 | — | — | 1 | 8.40 |
| CHEMBL2011941 | — | — | 1 | 8.40 |
| CHEMBL2011934 | — | — | 1 | 8.30 |
| CHEMBL2011930 | — | — | 1 | 8.15 |
| CHEMBL2011935 | — | — | 1 | 8.10 |
| CHEMBL2011943 | — | — | 1 | 8.05 |
| CHEMBL2011936 | — | — | 1 | 8.00 |
| CHEMBL2011929 | — | — | 1 | 8.00 |
| CHEMBL2011931 | — | — | 1 | 7.75 |
| CHEMBL2011944 | — | — | 1 | 7.50 |
| CHEMBL2010815 | — | — | 1 | 7.42 |
| CHEMBL2011927 | — | — | 1 | 7.41 |
| CHEMBL2011945 | — | — | 1 | 7.40 |
| CHEMBL2011939 | — | — | 1 | 7.34 |
| CHEMBL2011926 | — | — | 1 | 7.24 |
| CHEMBL2011938 | — | — | 1 | 7.23 |
| CHEMBL2011910 | — | — | 1 | 7.19 |
| CHEMBL2011928 | — | — | 1 | 7.16 |
| CHEMBL2011912 | — | — | 1 | 7.03 |
| CHEMBL2011899 | — | — | 1 | 6.98 |
| CHEMBL2011918 | — | — | 1 | 6.97 |
| CHEMBL2011937 | — | — | 1 | 6.97 |
| CHEMBL2011911 | — | — | 1 | 6.96 |
| CHEMBL2011895 | — | — | 1 | 6.82 |
| CHEMBL2011923 | — | — | 1 | 6.79 |
| CHEMBL2011917 | — | — | 1 | 6.75 |
| CHEMBL2011920 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011940 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2011932 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2011941 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2011933 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2011942 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2011934 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2011930 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2011935 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2011943 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2011936 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2011929 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2011931 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2011944 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2010815 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2011927 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2011945 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2011939 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2011926 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2011938 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2011910 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2011928 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2011912 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2011899 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2011918 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2011937 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2011911 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL2011895 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2011923 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL2011917 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL2011920 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL2011919 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL2011906 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL2011915 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL2011904 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL2011908 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL2011916 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL2011907 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL2011921 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL2011903 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL2011913 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL2011924 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL2011914 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL2011901 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL2011900 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL2011896 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL2011905 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2011922 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL2011897 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL2011902 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL2011909 | — | IC50 | = | 9550.0 | nM | 5.02 |