Assay Detail
Binding
CHEMBL2013394
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Inhibition of iNOS-induced NO production in LPS-stimulated mouse BV2 cells after 24 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.08 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2013188 | — | — | 1 | 5.33 |
| CHEMBL16171 | WOGONIN | — | 1 | 5.11 |
| CHEMBL2013189 | — | — | 1 | 5.07 |
| CHEMBL2013192 | — | — | 1 | 4.96 |
| CHEMBL2013190 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2013188 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL16171 | WOGONIN | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2013189 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL2013192 | — | IC50 | = | 10840.0 | nM | 4.96 |
| CHEMBL2013190 | — | IC50 | = | 11420.0 | nM | 4.94 |