Assay Detail
Binding
CHEMBL2013617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat lens aldose reductase
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.72 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.17 |
| CHEMBL249447 | — | — | 1 | 6.52 |
| CHEMBL464507 | GUAJAVERIN | — | 1 | 6.50 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | 6.02 |
| CHEMBL177126 | — | — | 1 | 5.64 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 5.36 |
| CHEMBL234316 | — | — | 2 | 5.13 |
| CHEMBL498879 | NICOTIFLOROSIDE | — | 1 | 4.95 |
| CHEMBL258394 | NARCISSIN | — | 1 | 4.92 |
| CHEMBL2011519 | — | — | 1 | - |
| CHEMBL506678 | SITOGLUSIDE | 2.0 | 1 | - |
| CHEMBL487783 | — | — | 1 | - |
| CHEMBL463487 | CITRUSIN C | — | 1 | - |
| CHEMBL501416 | GYMNASTERKOREAYNE E | — | 1 | - |
| CHEMBL463634 | GYMNASTERKOREAYNE A | — | 1 | - |
| CHEMBL2011645 | — | — | 1 | - |
| CHEMBL2011644 | — | — | 1 | - |
| CHEMBL2011643 | — | — | 1 | - |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL249447 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL464507 | GUAJAVERIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL177126 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL250450 | ISOQUERCETIN | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL234316 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL234316 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL498879 | NICOTIFLOROSIDE | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL258394 | NARCISSIN | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL2011519 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL506678 | SITOGLUSIDE | IC50 | > | 30000.0 | nM | - |
| CHEMBL487783 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL463487 | CITRUSIN C | IC50 | > | 30000.0 | nM | - |
| CHEMBL501416 | GYMNASTERKOREAYNE E | IC50 | > | 30000.0 | nM | - |
| CHEMBL463634 | GYMNASTERKOREAYNE A | IC50 | > | 30000.0 | nM | - |
| CHEMBL2011645 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2011644 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2011643 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL225304 | PIMAGEDINE | IC50 | > | 30000.0 | nM | - |