Assay Detail
Binding
CHEMBL2014296
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Binding affinity to human recombinant carbonic anhydrase-1 by thermal shift assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 22 | 6.86 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2010994 | — | — | 1 | 8.72 |
| CHEMBL2011158 | — | — | 1 | 8.17 |
| CHEMBL2010996 | — | — | 1 | 7.77 |
| CHEMBL2010992 | — | — | 1 | 7.77 |
| CHEMBL2010998 | — | — | 1 | 7.66 |
| CHEMBL2011000 | — | — | 1 | 7.52 |
| CHEMBL2011153 | — | — | 1 | 7.48 |
| CHEMBL2010990 | — | — | 1 | 7.48 |
| CHEMBL2011154 | — | — | 1 | 7.38 |
| CHEMBL2011156 | — | — | 1 | 7.17 |
| CHEMBL2010988 | — | — | 1 | 7.17 |
| CHEMBL2010993 | — | — | 1 | 7.00 |
| CHEMBL2010989 | — | — | 1 | 6.35 |
| CHEMBL2010991 | — | — | 1 | 6.17 |
| CHEMBL2011157 | — | — | 1 | 6.08 |
| CHEMBL2010987 | — | — | 1 | 6.08 |
| CHEMBL2010997 | — | — | 1 | 6.00 |
| CHEMBL2011152 | — | — | 1 | 6.00 |
| CHEMBL2010995 | — | — | 1 | 5.92 |
| CHEMBL2010807 | — | — | 1 | 5.85 |
| CHEMBL2010999 | — | — | 1 | 5.75 |
| CHEMBL2011155 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2010994 | — | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL2011158 | — | Kd | = | 6.7 | nM | 8.17 |
| CHEMBL2010996 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL2010992 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL2010998 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL2011000 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL2011153 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL2010990 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL2011154 | — | Kd | = | 42.0 | nM | 7.38 |
| CHEMBL2011156 | — | Kd | = | 67.0 | nM | 7.17 |
| CHEMBL2010988 | — | Kd | = | 67.0 | nM | 7.17 |
| CHEMBL2010993 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL2010989 | — | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL2010991 | — | Kd | = | 670.0 | nM | 6.17 |
| CHEMBL2011157 | — | Kd | = | 830.0 | nM | 6.08 |
| CHEMBL2010987 | — | Kd | = | 830.0 | nM | 6.08 |
| CHEMBL2010997 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL2011152 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL2010995 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL2010807 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL2010999 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL2011155 | — | Kd | = | 4500.0 | nM | 5.35 |