Assay Detail
Binding
CHEMBL2014329
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Transactivation of GAL4-fused PPARalpha LBD expressed in HepG2 cells after 20 hrs by luminescence assay
13
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.84 | 6.05 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557555 | CIPROFIBRATE | 4.0 | 1 | 6.05 |
| CHEMBL2011544 | — | — | 2 | 5.40 |
| CHEMBL2011543 | — | — | 2 | 4.80 |
| CHEMBL2011541 | — | — | 2 | 4.71 |
| CHEMBL2011545 | — | — | 1 | 4.34 |
| CHEMBL108861 | METHYLEUGENOL | — | 1 | 4.33 |
| CHEMBL2011540 | PIPERITOL | — | 1 | 4.27 |
| CHEMBL2011538 | — | — | 1 | - |
| CHEMBL2011539 | PLUVIATILOL | — | 1 | - |
| CHEMBL487611 | PINORESINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557555 | CIPROFIBRATE | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2011544 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2011543 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL2011541 | — | EC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL2011545 | — | EC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL108861 | METHYLEUGENOL | EC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL2011540 | PIPERITOL | EC50 | = | 53200.0 | nM | 4.27 |
| CHEMBL2011538 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL2011539 | PLUVIATILOL | EC50 | > | 60000.0 | nM | - |
| CHEMBL487611 | PINORESINOL | EC50 | > | 60000.0 | nM | - |
| CHEMBL2011541 | — | Activity | - | — | - | |
| CHEMBL2011543 | — | Activity | - | — | - | |
| CHEMBL2011544 | — | Activity | - | — | - |