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Compound Detail

CHEMBL557555

CIPROFIBRATE
💊 Approved Drug
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💊 Approved Drug
CC(C)(Oc1ccc(C2CC2(Cl)Cl)cc1)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL557555
Name CIPROFIBRATE
Phase Approved
Structure Type MOL
InChI Key KPSRODZRAIWAKH-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Ciprofibrate Ciprofibrato Modalim NSC-759617 WIN 35833 WIN-35833
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
20
Publications
6
Known Names
1
Indications
1
Mechanisms

Molecular Properties

289.2
MW (Da)
3.59
ALogP
2
HBA
1
HBD
46.5
PSA (Ų)
0.86
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1985
Availability Unknown
Chirality Racemic

Routes of Administration

Oral

Flags

Natural Product
USAN Stem -fibrate
USAN Year 1976

Extended Properties

Molecular Formula C13H14Cl2O3
MW 289.16
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness 0.38

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Peroxisome proliferator-activated receptor alpha agonist AGONIST Peroxisome proliferator-activated receptor alpha ✓ ✓

Indications

Cardiovascular Diseases

ATC Classification

C10AB08
ciprofibrate
Level 1: CARDIOVASCULAR SYSTEM
Level 2: LIPID MODIFYING AGENTS

Activity Summary

EC50 2 meas. best 6.05
IC50 2 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor alpha
CHEMBL239
 EC50 6.05 6.05 900.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Peroxisome proliferator-activated receptor alpha EC50 = 900.0 nM 6.05 Transactivation of GAL4-fused PPARalpha LBD expressed in HepG2 cells after 20 hr... 22381047
Peroxisome proliferator-activated receptor alpha EC50 = 900.0 nM 6.05 Transactivation of GAL4-fused PPARalpha ligand binding domain transfected in hum... 23031596

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 3
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
21965623 10.1124/dmd.111.040758 Bile salt export pump 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Peroxisome proliferator-activated receptor alpha 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Peroxisome proliferator-activated receptor gamma 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
19663428 10.1021/jm801349e Fatty acid-binding protein, liver 2

Data from ChEMBL 36 via Core Engine