Assay Detail
Binding
CHEMBL2162785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of GAL4-fused PPARalpha ligand binding domain transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.92 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557555 | CIPROFIBRATE | 4.0 | 1 | 6.05 |
| CHEMBL458899 | — | — | 1 | 4.37 |
| CHEMBL2159605 | PLANTAGINEOSIDE A | — | 1 | 4.33 |
| CHEMBL465800 | — | — | 1 | - |
| CHEMBL516827 | — | — | 1 | - |
| CHEMBL2159607 | PLANTAGINEOSIDE C | — | 1 | - |
| CHEMBL2159606 | PLANTAGINEOSIDE B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557555 | CIPROFIBRATE | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL458899 | — | EC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL2159605 | PLANTAGINEOSIDE A | EC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL465800 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL516827 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL2159607 | PLANTAGINEOSIDE C | EC50 | > | 50000.0 | nM | - |
| CHEMBL2159606 | PLANTAGINEOSIDE B | EC50 | > | 50000.0 | nM | - |