Assay Detail
Functional
CHEMBL2014336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 infected in human MT-4 cells assessed as inhibition of viral-induced cytopathogenicity after 4 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.07 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012671 | — | — | 1 | 8.82 |
| CHEMBL322215 | — | — | 1 | 8.32 |
| CHEMBL2012669 | — | — | 1 | 8.26 |
| CHEMBL2012670 | — | — | 1 | 8.01 |
| CHEMBL2012667 | — | — | 1 | 7.96 |
| CHEMBL2012668 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012671 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL322215 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2012669 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2012670 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2012667 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2012668 | — | EC50 | = | 87.0 | nM | 7.06 |