Assay Detail
Functional
CHEMBL2014341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of viral-induced cytopathogenicity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.51 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012667 | — | — | 1 | 5.19 |
| CHEMBL2012669 | — | — | 1 | 4.57 |
| CHEMBL2012668 | — | — | 1 | 4.28 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012667 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2012669 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2012668 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 100000.0 | nM | 4.00 |