Assay Detail
Binding
CHEMBL2014361
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Displacement of [3H]CGS21680 from human recombinant adenosine receptor-2A expressed in HEK293 cell membrane after 60 mins by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.43 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012678 | — | — | 1 | 5.61 |
| CHEMBL2012675 | — | — | 1 | 5.57 |
| CHEMBL2012674 | — | — | 1 | 5.52 |
| CHEMBL2012672 | — | — | 1 | 5.50 |
| CHEMBL2012683 | — | — | 1 | 5.43 |
| CHEMBL2012673 | — | — | 1 | 5.43 |
| CHEMBL2012676 | — | — | 1 | 5.41 |
| CHEMBL2012686 | — | — | 1 | 5.40 |
| CHEMBL2012679 | — | — | 1 | 5.39 |
| CHEMBL2012684 | — | — | 1 | 5.36 |
| CHEMBL2012693 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012678 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL2012675 | — | Ki | = | 2720.0 | nM | 5.57 |
| CHEMBL2012674 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL2012672 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL2012683 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL2012673 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL2012676 | — | Ki | = | 3930.0 | nM | 5.41 |
| CHEMBL2012686 | — | Ki | = | 3950.0 | nM | 5.40 |
| CHEMBL2012679 | — | Ki | = | 4080.0 | nM | 5.39 |
| CHEMBL2012684 | — | Ki | = | 4410.0 | nM | 5.36 |
| CHEMBL2012693 | — | Ki | = | 7510.0 | nM | 5.12 |