Assay Detail
Binding
CHEMBL2014392
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Inhibition of human erythrocyte AChE assessed as acetylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry
21
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.79 | 6.82 |
| Inhibition | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.82 |
| CHEMBL223256 | NYMPHAEOL A | — | 2 | 5.14 |
| CHEMBL2011403 | — | — | 2 | 4.81 |
| CHEMBL2011405 | — | — | 2 | 4.64 |
| CHEMBL2011402 | — | — | 2 | 4.50 |
| CHEMBL459258 | — | — | 2 | 4.31 |
| CHEMBL374130 | BONANNIONE A | — | 2 | 4.04 |
| CHEMBL2011404 | — | — | 2 | 4.03 |
| CHEMBL253152 | — | — | 2 | - |
| CHEMBL2011406 | — | — | 1 | - |
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | - |
| CHEMBL9352 | NARINGENIN | — | 1 | - |
| CHEMBL8996 | ERIODICTYOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL223256 | NYMPHAEOL A | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2011403 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL2011405 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL2011402 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL459258 | — | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL374130 | BONANNIONE A | IC50 | = | 91500.0 | nM | 4.04 |
| CHEMBL2011404 | — | IC50 | = | 92400.0 | nM | 4.03 |
| CHEMBL253152 | — | Inhibition | - | % | - | |
| CHEMBL2011405 | — | Inhibition | - | % | - | |
| CHEMBL374130 | BONANNIONE A | Inhibition | - | % | - | |
| CHEMBL223256 | NYMPHAEOL A | Inhibition | - | % | - | |
| CHEMBL2011402 | — | Inhibition | - | % | - | |
| CHEMBL2011404 | — | Inhibition | - | % | - | |
| CHEMBL2011403 | — | Inhibition | - | % | - | |
| CHEMBL2011406 | — | IC50 | = | 316300.0 | nM | - |
| CHEMBL399121 | HESPERETIN | IC50 | = | 2476100.0 | nM | - |
| CHEMBL9352 | NARINGENIN | IC50 | = | 2045000.0 | nM | - |
| CHEMBL8996 | ERIODICTYOL | IC50 | = | 1663800.0 | nM | - |
| CHEMBL459258 | — | Inhibition | - | % | - | |
| CHEMBL253152 | — | IC50 | = | 109200.0 | nM | - |