Assay Detail
Binding
CHEMBL2014405
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Displacement of [3H]R-PIA from rat forebrain adenosine receptor-1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.00 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012678 | — | — | 1 | 9.47 |
| CHEMBL2012674 | — | — | 1 | 9.15 |
| CHEMBL2012679 | — | — | 1 | 9.15 |
| CHEMBL2012684 | — | — | 1 | 9.10 |
| CHEMBL2012686 | — | — | 1 | 9.10 |
| CHEMBL2012675 | — | — | 1 | 9.05 |
| CHEMBL2012682 | — | — | 1 | 8.72 |
| CHEMBL2012687 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012678 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL2012674 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL2012679 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL2012684 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL2012686 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL2012675 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2012682 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL2012687 | — | Ki | = | 6.0 | nM | 8.22 |