Assay Detail
Binding
CHEMBL2015198
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Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins by spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.56 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011495 | — | — | 1 | 9.51 |
| CHEMBL2011487 | — | — | 1 | 9.38 |
| CHEMBL1994202 | — | — | 1 | 9.37 |
| CHEMBL536047 | — | — | 1 | 9.16 |
| CHEMBL2011491 | — | — | 1 | 9.13 |
| CHEMBL2011483 | — | — | 1 | 9.05 |
| CHEMBL3216777 | — | — | 1 | 8.88 |
| CHEMBL2011496 | — | — | 1 | 8.88 |
| CHEMBL2011488 | — | — | 1 | 8.86 |
| CHEMBL3215882 | — | — | 1 | 8.72 |
| CHEMBL3216556 | — | — | 1 | 8.69 |
| CHEMBL3216778 | — | — | 1 | 8.49 |
| CHEMBL3216116 | — | — | 1 | 8.45 |
| CHEMBL3216555 | — | — | 1 | 8.40 |
| CHEMBL3216554 | — | — | 1 | 8.38 |
| CHEMBL3217208 | — | — | 1 | 8.16 |
| CHEMBL3216779 | — | — | 1 | 8.04 |
| CHEMBL3216557 | — | — | 1 | 7.94 |
| CHEMBL292314 | — | — | 1 | 7.88 |
| CHEMBL2011499 | — | — | 1 | 7.87 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011495 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL2011487 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL1994202 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL536047 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL2011491 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL2011483 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL3216777 | — | IC50 | = | 1.33 | nM | 8.88 |
| CHEMBL2011496 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL2011488 | — | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL3215882 | — | IC50 | = | 1.89 | nM | 8.72 |
| CHEMBL3216556 | — | IC50 | = | 2.04 | nM | 8.69 |
| CHEMBL3216778 | — | IC50 | = | 3.26 | nM | 8.49 |
| CHEMBL3216116 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL3216555 | — | IC50 | = | 4.02 | nM | 8.40 |
| CHEMBL3216554 | — | IC50 | = | 4.19 | nM | 8.38 |
| CHEMBL3217208 | — | IC50 | = | 6.84 | nM | 8.16 |
| CHEMBL3216779 | — | IC50 | = | 9.09 | nM | 8.04 |
| CHEMBL3216557 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL292314 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL2011499 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL95 | TACRINE | IC50 | = | 317.0 | nM | 6.50 |