Assay Detail
Binding
CHEMBL2015199
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Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins by spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.24 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011483 | — | — | 1 | 7.61 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.61 |
| CHEMBL3216554 | — | — | 1 | 7.58 |
| CHEMBL3216778 | — | — | 1 | 7.57 |
| CHEMBL2011496 | — | — | 1 | 7.46 |
| CHEMBL2011487 | — | — | 1 | 7.36 |
| CHEMBL3216116 | — | — | 1 | 7.36 |
| CHEMBL3216557 | — | — | 1 | 7.32 |
| CHEMBL2011495 | — | — | 1 | 7.29 |
| CHEMBL3216555 | — | — | 1 | 7.13 |
| CHEMBL2011488 | — | — | 1 | 7.13 |
| CHEMBL3216779 | — | — | 1 | 7.12 |
| CHEMBL2011491 | — | — | 1 | 7.12 |
| CHEMBL3216556 | — | — | 1 | 7.06 |
| CHEMBL3215882 | — | — | 1 | 7.06 |
| CHEMBL3216777 | — | — | 1 | 6.88 |
| CHEMBL3217208 | — | — | 1 | 6.86 |
| CHEMBL536047 | — | — | 1 | 6.76 |
| CHEMBL1994202 | — | — | 1 | - |
| CHEMBL2011499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011483 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL95 | TACRINE | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL3216554 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL3216778 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL2011496 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL2011487 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL3216116 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL3216557 | — | IC50 | = | 47.4 | nM | 7.32 |
| CHEMBL2011495 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL3216555 | — | IC50 | = | 73.3 | nM | 7.13 |
| CHEMBL2011488 | — | IC50 | = | 74.2 | nM | 7.13 |
| CHEMBL3216779 | — | IC50 | = | 76.6 | nM | 7.12 |
| CHEMBL2011491 | — | IC50 | = | 75.2 | nM | 7.12 |
| CHEMBL3216556 | — | IC50 | = | 86.8 | nM | 7.06 |
| CHEMBL3215882 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL3216777 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3217208 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL536047 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL1994202 | — | IC50 | - | — | - | |
| CHEMBL2011499 | — | IC50 | - | — | - |