Assay Detail
Functional
CHEMBL2015387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human GRANTA-519 cells after 96 hrs by trypan blue exclusion assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Granta-519 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.82 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1771376 | — | — | 1 | 8.52 |
| CHEMBL2013119 | RIGOSERTIB SODIUM | 3.0 | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1771376 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2013119 | RIGOSERTIB SODIUM | IC50 | = | 75.0 | nM | 7.12 |