Assay Detail
Binding
CHEMBL2015542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LRRK2 G2019S mutant expressed in HEK293 cells using nictide and ATP as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Leucine-rich repeat serine/threonine-protein kinase 2 (CHEMBL1075104) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012582 | — | — | 1 | 8.22 |
| CHEMBL509032 | TAE-684 | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012582 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL509032 | TAE-684 | IC50 | = | 6.1 | nM | 8.21 |