Assay Detail
Binding
CHEMBL2015667
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Inhibition of Yersinia pseudotuberculosis YopH
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Yersinia pseudotuberculosis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase YopH (CHEMBL5835) ↗| Type | SINGLE PROTEIN |
| Organism | Yersinia pseudotuberculosis serotype I (strain IP32953) |
Publication
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.49 | 4.75 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2010868 | — | — | 1 | 4.75 |
| CHEMBL1231350 | — | — | 1 | 4.22 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2010868 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1231350 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 1000000.0 | nM | - |