Assay Detail
Functional
CHEMBL2015750
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Antiproliferative activity against mouse LM05e cells assessed as decrease in cell number after 72 hrs by WST assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel alkynylphosphonate analogue of calcitriol with potent antiproliferative effects in cancer cells and lack of calcemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.65 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.52 |
| CHEMBL2011468 | — | — | 1 | 8.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL2011468 | — | IC50 | = | 1.68 | nM | 8.78 |