Assay Detail
Functional
CHEMBL2015764
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 production incubated for 2 hrs prior to LPS-challenge measured after 22 hrs by ELISA
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 5 | - | - |
| IC50 | 5 | 5.27 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130639 | — | — | 2 | 5.57 |
| CHEMBL593439 | — | — | 2 | 5.27 |
| CHEMBL2013138 | — | — | 2 | 5.26 |
| CHEMBL285901 | — | — | 2 | 5.16 |
| CHEMBL2013137 | — | — | 2 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130639 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL593439 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL2013138 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL285901 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL2013137 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL130639 | — | Inhibition | - | % | - | |
| CHEMBL2013137 | — | Inhibition | - | % | - | |
| CHEMBL2013138 | — | Inhibition | - | % | - | |
| CHEMBL285901 | — | Inhibition | - | % | - | |
| CHEMBL593439 | — | Inhibition | - | % | - |