Assay Detail
Functional
CHEMBL2015765
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production incubated for 2 hrs prior to LPS-challenge measured after 22 hrs by ELISA
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 5 | - | - |
| IC50 | 5 | 5.14 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593439 | — | — | 2 | 5.56 |
| CHEMBL285901 | — | — | 2 | 5.54 |
| CHEMBL2013137 | — | — | 2 | 5.13 |
| CHEMBL2013138 | — | — | 2 | 5.08 |
| CHEMBL130639 | — | — | 2 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593439 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL285901 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2013137 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL2013138 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL130639 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL130639 | — | Inhibition | - | % | - | |
| CHEMBL2013137 | — | Inhibition | - | % | - | |
| CHEMBL2013138 | — | Inhibition | - | % | - | |
| CHEMBL285901 | — | Inhibition | - | % | - | |
| CHEMBL593439 | — | Inhibition | - | % | - |