Assay Detail
Binding
CHEMBL2015863
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Inhibition of recombinant glucosylceramidase 1 using 4-methylumbelliferyl-B-glucoside as substrate by fluorimetric analysis
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 4.85 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574645 | — | — | 1 | 6.70 |
| CHEMBL2011641 | — | — | 1 | 6.48 |
| CHEMBL1086996 | — | — | 1 | 5.70 |
| CHEMBL2011642 | — | — | 1 | 5.66 |
| CHEMBL2011626 | — | — | 1 | 5.00 |
| CHEMBL2011634 | — | — | 1 | 4.70 |
| CHEMBL2011603 | — | — | 1 | 4.30 |
| CHEMBL2011606 | — | — | 1 | 4.19 |
| CHEMBL2011636 | — | — | 1 | 4.10 |
| CHEMBL2011622 | — | — | 1 | 4.10 |
| CHEMBL2011608 | — | — | 1 | 4.10 |
| CHEMBL2011612 | — | — | 1 | 4.00 |
| CHEMBL2011620 | — | — | 1 | 4.00 |
| CHEMBL2011640 | — | — | 1 | - |
| CHEMBL2011639 | — | — | 1 | - |
| CHEMBL1818439 | — | — | 1 | - |
| CHEMBL2011638 | — | — | 1 | - |
| CHEMBL2011637 | — | — | 1 | - |
| CHEMBL1818435 | — | — | 1 | - |
| CHEMBL2011635 | — | — | 1 | - |
| CHEMBL505237 | — | — | 1 | - |
| CHEMBL2011633 | — | — | 1 | - |
| CHEMBL1818436 | — | — | 1 | - |
| CHEMBL456583 | — | — | 1 | - |
| CHEMBL2011632 | — | — | 1 | - |
| CHEMBL2011631 | — | — | 1 | - |
| CHEMBL1818437 | — | — | 1 | - |
| CHEMBL2011630 | — | — | 1 | - |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | - |
| CHEMBL2011629 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574645 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2011641 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1086996 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2011642 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2011626 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2011634 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2011603 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2011606 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2011608 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2011622 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2011636 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2011612 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2011620 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2011617 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL108084 | FAGOMINE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011604 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011605 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011607 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011609 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL2011610 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011611 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011613 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011614 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011615 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL2011616 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011628 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL2011618 | — | IC50 | = | 350000.0 | nM | - |
| CHEMBL2011619 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL2011621 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL2011623 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011624 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL505237 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011629 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 400000.0 | nM | - |
| CHEMBL2011630 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL1818437 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011631 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011632 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL456583 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL1818436 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011633 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011602 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011635 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1818435 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011637 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011638 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL1818439 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011639 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2011640 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL2011601 | — | IC50 | > | 1000000.0 | nM | - |