Assay Detail
Functional
CHEMBL2016105
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Cytotoxicity against human COLO205 cells after 72 hrs by MTS assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 8.09 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012890 | — | — | 1 | 9.00 |
| CHEMBL2012902 | — | — | 1 | 9.00 |
| CHEMBL2012908 | — | — | 1 | 9.00 |
| CHEMBL2012891 | — | — | 1 | 8.70 |
| CHEMBL2012893 | — | — | 1 | 8.70 |
| CHEMBL2012892 | — | — | 1 | 8.60 |
| CHEMBL2012909 | — | — | 1 | 8.52 |
| CHEMBL2012907 | — | — | 1 | 8.30 |
| CHEMBL2012894 | — | — | 1 | 8.30 |
| CHEMBL2012895 | — | — | 1 | 8.05 |
| CHEMBL2012899 | — | — | 1 | 8.00 |
| CHEMBL2012903 | — | — | 1 | 7.92 |
| CHEMBL2012906 | — | — | 1 | 7.92 |
| CHEMBL1169814 | — | — | 1 | 7.92 |
| CHEMBL2012901 | — | — | 1 | 7.77 |
| CHEMBL2012905 | — | — | 1 | 7.57 |
| CHEMBL2012896 | — | — | 1 | 7.47 |
| CHEMBL2012904 | — | — | 1 | 7.36 |
| CHEMBL2012897 | — | — | 1 | 7.28 |
| CHEMBL2012898 | — | — | 1 | 7.24 |
| CHEMBL2012900 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012890 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2012902 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2012908 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2012891 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2012893 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2012892 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2012909 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2012907 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2012894 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2012895 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2012899 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012903 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2012906 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1169814 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2012901 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2012905 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2012896 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2012904 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2012897 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2012898 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2012900 | — | EC50 | = | 62.0 | nM | 7.21 |