Compound Detail
CHEMBL2012892
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Basic Information
| ChEMBL ID | CHEMBL2012892 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WRVBDJLAGINJKL-LLVKDONJSA-N |
3
Targets
3
Activities
2
Assay Types
4
PK Parameters
20
Publications
0
Known Names
Molecular Properties
517.3
MW (Da)
2.05
ALogP
7
HBA
4
HBD
112.8
PSA (Ų)
0.33
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.6
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| COLO 205 CHEMBL614561 | EC50 | 8.6 | 8.6 | 2.5 | 1 |
| A-375 CHEMBL613859 | EC50 | 8.52 | 8.52 | 3.0 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 23.7 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 12.0 | % | Rattus norvegicus |
| T1/2 | 0.4333 | hr | Rattus norvegicus |
| T1/2 | 0.6 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| COLO 205 | EC50 | = | 2.5 | nM | 8.6 | Cytotoxicity against human COLO205 cells after 72 hrs by MTS assay | 22406151 |
| A-375 | EC50 | = | 3.0 | nM | 8.52 | Cytotoxicity against human A375 cells after 72 hrs by MTS assay | 22406151 |
| Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of MEK1-mediated ERK1 phosphorylation using IPTTPITTYFFFK-5FAM-COOH a... | 22406151 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Rattus norvegicus | 4 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Liver microsomes | 2 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Calcium/calmodulin-dependent protein kinase type 1D | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | ADMET | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Protein kinase C alpha type | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | COLO 205 | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | A-375 | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Tyrosine-protein kinase ABL1 | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | RAC-gamma serine/threonine-protein kinase | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Cyclin-dependent kinase 2/cyclin A | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Hepatocyte growth factor receptor | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Epidermal growth factor receptor | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Glycogen synthase kinase-3 beta | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Insulin receptor | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Tyrosine-protein kinase JAK3 | 1 |
| 22406151 | 10.1016/j.bmcl.2012.02.026 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine