Assay Detail
Functional
CHEMBL2016330
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Cytotoxicity against human A375 cells after 72 hrs by MTS assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.86 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012890 | — | — | 1 | 9.00 |
| CHEMBL2012908 | — | — | 1 | 8.70 |
| CHEMBL2012891 | — | — | 1 | 8.60 |
| CHEMBL2012892 | — | — | 1 | 8.52 |
| CHEMBL2012902 | — | — | 1 | 8.52 |
| CHEMBL2012893 | — | — | 1 | 8.40 |
| CHEMBL2012909 | — | — | 1 | 8.30 |
| CHEMBL2012894 | — | — | 1 | 8.15 |
| CHEMBL2012907 | — | — | 1 | 7.89 |
| CHEMBL2012895 | — | — | 1 | 7.89 |
| CHEMBL1169814 | — | — | 1 | 7.85 |
| CHEMBL2012899 | — | — | 1 | 7.82 |
| CHEMBL2012903 | — | — | 1 | 7.52 |
| CHEMBL2012896 | — | — | 1 | 7.51 |
| CHEMBL2012906 | — | — | 1 | 7.48 |
| CHEMBL2012901 | — | — | 1 | 7.47 |
| CHEMBL2012905 | — | — | 1 | 7.16 |
| CHEMBL2012898 | — | — | 1 | 7.14 |
| CHEMBL2012900 | — | — | 1 | 7.14 |
| CHEMBL2012897 | — | — | 1 | 7.12 |
| CHEMBL2012904 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012890 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2012908 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2012891 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2012892 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2012902 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2012893 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2012909 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2012894 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2012907 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2012895 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1169814 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2012899 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2012903 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012896 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2012906 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2012901 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2012905 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2012898 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2012900 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2012897 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2012904 | — | EC50 | = | 139.0 | nM | 6.86 |