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Assay Detail

CHEMBL2016145

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX1 after 5 mins by spectrophotometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL221)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-Caffeoyl serotonin as selective COX-2 inhibitor.
Takahashi T, Miyazawa M.
Bioorg Med Chem Lett (2012) 22 : 2494 -2496
PubMed 22386242 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 4.41 4.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109341 SINAPINATE 1 4.41
CHEMBL559089 N-CAFFEOYLSEROTONIN 1 -
CHEMBL1760551 N-SINAPOYL SEROTONIN 1 -
CHEMBL145 CAFFEIC ACID 3.0 1 -
CHEMBL39 SEROTONIN 3.0 1 -
CHEMBL25 ASPIRIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109341 SINAPINATE IC50 = 39200.0 nM 4.41
CHEMBL559089 N-CAFFEOYLSEROTONIN IC50 > 400000.0 nM -
CHEMBL1760551 N-SINAPOYL SEROTONIN IC50 > 400000.0 nM -
CHEMBL145 CAFFEIC ACID IC50 > 400000.0 nM -
CHEMBL39 SEROTONIN IC50 > 400000.0 nM -
CHEMBL25 ASPIRIN IC50 = 560100.0 nM -