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Assay Detail

CHEMBL2016177

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SK-N-SH cells after 48 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-SH
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-SH (CHEMBL614924)
Type CELL-LINE
Organism Homo sapiens

Publication

Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity.
Subba Reddy BV, Rajeswari N, Sarangapani M, Prashanthi Y, Ganji RJ, Addlagatta A.
Bioorg Med Chem Lett (2012) 22 : 2460 -2463
PubMed 22386528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.79 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL557057 1 6.05
CHEMBL2011861 1 6.03
CHEMBL2011862 1 6.03
CHEMBL551943 1 6.03
CHEMBL53463 DOXORUBICIN 4.0 1 6.01
CHEMBL563481 1 6.01
CHEMBL2011863 1 6.01
CHEMBL1222953 1 6.00
CHEMBL2011869 1 5.98
CHEMBL2011866 1 5.91
CHEMBL2011865 1 5.89
CHEMBL1222880 1 5.88
CHEMBL564411 1 5.88
CHEMBL15844 INDOLE 1 5.75
CHEMBL2011864 1 5.02
CHEMBL326294 ISATIN 1 5.01
CHEMBL2011868 1 5.00
CHEMBL2011867 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL557057 IC50 = 900.0 nM 6.05
CHEMBL2011861 IC50 = 940.0 nM 6.03
CHEMBL2011862 IC50 = 940.0 nM 6.03
CHEMBL551943 IC50 = 930.0 nM 6.03
CHEMBL53463 DOXORUBICIN IC50 = 970.0 nM 6.01
CHEMBL563481 IC50 = 980.0 nM 6.01
CHEMBL2011863 IC50 = 980.0 nM 6.01
CHEMBL1222953 IC50 = 990.0 nM 6.00
CHEMBL2011869 IC50 = 1040.0 nM 5.98
CHEMBL2011866 IC50 = 1230.0 nM 5.91
CHEMBL2011865 IC50 = 1280.0 nM 5.89
CHEMBL1222880 IC50 = 1310.0 nM 5.88
CHEMBL564411 IC50 = 1320.0 nM 5.88
CHEMBL15844 INDOLE IC50 = 1780.0 nM 5.75
CHEMBL2011864 IC50 = 9600.0 nM 5.02
CHEMBL326294 ISATIN IC50 = 9840.0 nM 5.01
CHEMBL2011868 IC50 = 9900.0 nM 5.00
CHEMBL2011867 IC50 > 100000.0 nM -