Assay Detail
Binding
CHEMBL2019406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.75 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 9.38 |
| CHEMBL43185 | PIPERINE | 2.0 | 1 | 6.39 |
| CHEMBL2018554 | — | — | 1 | 6.10 |
| CHEMBL2018555 | — | — | 1 | 5.89 |
| CHEMBL120544 | — | — | 1 | 5.69 |
| CHEMBL42965 | METHYL PIPERATE | — | 1 | 5.56 |
| CHEMBL2018561 | — | — | 1 | 5.50 |
| CHEMBL484378 | — | — | 1 | 5.44 |
| CHEMBL483373 | — | — | 1 | 5.42 |
| CHEMBL457218 | — | — | 1 | 5.28 |
| CHEMBL2018562 | — | — | 1 | 5.25 |
| CHEMBL2018556 | — | — | 1 | 5.12 |
| CHEMBL2018559 | — | — | 1 | 4.79 |
| CHEMBL332122 | PIPERIC ACID | — | 1 | 4.74 |
| CHEMBL332479 | TETRAHYDROPIPERINE | — | 1 | - |
| CHEMBL2018558 | — | — | 1 | - |
| CHEMBL2018557 | — | — | 1 | - |
| CHEMBL2018560 | — | — | 1 | - |
| CHEMBL418484 | — | — | 1 | - |
| CHEMBL450300 | — | — | 1 | - |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL43185 | PIPERINE | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL2018554 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2018555 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL120544 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL42965 | METHYL PIPERATE | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL2018561 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL484378 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL483373 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL457218 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL2018562 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL2018556 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL2018559 | — | IC50 | = | 16080.0 | nM | 4.79 |
| CHEMBL332122 | PIPERIC ACID | IC50 | = | 18340.0 | nM | 4.74 |
| CHEMBL332479 | TETRAHYDROPIPERINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018557 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418484 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL450300 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL972 | SELEGILINE | IC50 | > | 100000.0 | nM | - |