Compound Detail
CHEMBL332479
TETRAHYDROPIPERINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL332479 |
| Name | TETRAHYDROPIPERINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APZYKUZPJCQGPP-UHFFFAOYSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
9
Publications
1
Known Names
Molecular Properties
289.4
MW (Da)
3.14
ALogP
3
HBA
0
HBD
38.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.71
EC50 1 meas. best 5.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B CHEMBL2993 | IC50 | 5.71 | 5.71 | 1970.0 | 1 |
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | EC50 | 5.2 | 5.2 | 6309.6 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.94 | 4.79 | 11520.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | IC50 | = | 1970.0 | nM | 5.71 | Inhibition of MAO-B in Sprague-Dawley rat brain homogenate using kynuramine as s... | 22475561 |
| Transient receptor potential cation channel subfamily V member 1 | EC50 | = | 6309.57 | nM | 5.2 | Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cell... | 20381363 |
| Trypanosoma cruzi | IC50 | = | 11520.0 | nM | 4.94 | In vitro growth inhibition of amastigotes of Trypanosoma cruzi | 15177472 |
| Trypanosoma cruzi | IC50 | = | 19000.0 | nM | 4.72 | Antimicrobial activity against Trypanosoma cruzi | 20185316 |
| Trypanosoma cruzi | IC50 | = | 19410.0 | nM | 4.71 | In vitro growth inhibition of epimastigotes of Trypanosoma cruzi | 15177472 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19523722 | 10.1016/j.ejmech.2009.05.004 | Quinolone resistance protein NorA | 5 |
| 20381363 | 10.1016/j.bmc.2010.03.013 | Transient receptor potential cation channel subfamily V member 1 | 3 |
| 15177472 | 10.1016/j.bmcl.2004.04.019 | Trypanosoma cruzi | 2 |
| 18848780 | 10.1016/j.bmc.2008.09.042 | Quinolone resistance protein NorA | 2 |
| 20185316 | 10.1016/j.bmc.2010.01.068 | Trypanosoma cruzi | 1 |
| 22475561 | 10.1016/j.bmcl.2012.02.090 | Amine oxidase [flavin-containing] A | 1 |
| 22475561 | 10.1016/j.bmcl.2012.02.090 | Amine oxidase [flavin-containing] B | 1 |
| - | 10.1007/s00044-008-9161-9 | Trypanosoma cruzi | 1 |
| 38665828 | 10.1039/d3md00455d | Glutamate NMDA receptor; GRIN1/GRIN2B | 1 |
Data from ChEMBL 36 via Core Engine