Assay Detail
Functional
CHEMBL812100
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In vitro growth inhibition of amastigotes of Trypanosoma cruzi
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.19 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.59 |
| CHEMBL43185 | PIPERINE | 2.0 | 1 | 5.31 |
| CHEMBL120919 | — | — | 1 | 5.24 |
| CHEMBL324315 | — | — | 1 | 5.13 |
| CHEMBL119395 | — | — | 1 | 5.11 |
| CHEMBL418484 | — | — | 1 | 5.02 |
| CHEMBL332479 | TETRAHYDROPIPERINE | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL43185 | PIPERINE | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL120919 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL324315 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL119395 | — | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL418484 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL332479 | TETRAHYDROPIPERINE | IC50 | = | 11520.0 | nM | 4.94 |