Compound Detail
CHEMBL324315
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL324315 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLKOUKNODPCIHZ-UMYWTXKFSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
3.55
ALogP
3
HBA
0
HBD
38.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | IC50 | 5.16 | 5.0867 | 7000.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma cruzi | IC50 | = | 7000.0 | nM | 5.16 | Antimicrobial activity against Trypanosoma cruzi | 20185316 |
| Trypanosoma cruzi | IC50 | = | 7400.0 | nM | 5.13 | In vitro growth inhibition of amastigotes of Trypanosoma cruzi | 15177472 |
| Trypanosoma cruzi | IC50 | = | 10670.0 | nM | 4.97 | In vitro growth inhibition of epimastigotes of Trypanosoma cruzi | 15177472 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27810594 | 10.1016/j.ejmech.2016.10.047 | Unchecked | 6 |
| 15177472 | 10.1016/j.bmcl.2004.04.019 | Trypanosoma cruzi | 2 |
| 30638966 | 10.1016/j.bmc.2018.12.043 | Polyunsaturated fatty acid 5-lipoxygenase | 2 |
| 20185316 | 10.1016/j.bmc.2010.01.068 | Trypanosoma cruzi | 1 |
| 30638966 | 10.1016/j.bmc.2018.12.043 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine