Assay Detail
Binding
CHEMBL2019407
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Inhibition of MAO-B in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.26 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.86 |
| CHEMBL484378 | — | — | 1 | 7.35 |
| CHEMBL483373 | — | — | 1 | 7.11 |
| CHEMBL42965 | METHYL PIPERATE | — | 1 | 6.64 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 6.58 |
| CHEMBL43185 | PIPERINE | 2.0 | 1 | 6.58 |
| CHEMBL2018556 | — | — | 1 | 6.48 |
| CHEMBL450300 | — | — | 1 | 6.48 |
| CHEMBL2018555 | — | — | 1 | 6.12 |
| CHEMBL120544 | — | — | 1 | 6.02 |
| CHEMBL2018562 | — | — | 1 | 5.91 |
| CHEMBL2018554 | — | — | 1 | 5.80 |
| CHEMBL457218 | — | — | 1 | 5.76 |
| CHEMBL2018561 | — | — | 1 | 5.75 |
| CHEMBL332479 | TETRAHYDROPIPERINE | — | 1 | 5.71 |
| CHEMBL2018559 | — | — | 1 | 5.46 |
| CHEMBL332122 | PIPERIC ACID | — | 1 | 4.87 |
| CHEMBL418484 | — | — | 1 | - |
| CHEMBL2018557 | — | — | 1 | - |
| CHEMBL2018558 | — | — | 1 | - |
| CHEMBL2018560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 13.91 | nM | 7.86 |
| CHEMBL484378 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL483373 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL42965 | METHYL PIPERATE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL43185 | PIPERINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2018556 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL450300 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2018555 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL120544 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL2018562 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL2018554 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL457218 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2018561 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL332479 | TETRAHYDROPIPERINE | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL2018559 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL332122 | PIPERIC ACID | IC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL418484 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018557 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2018560 | — | IC50 | > | 100000.0 | nM | - |