Assay Detail
Binding
CHEMBL2019768
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Inhibition of human recombinant Sky using poly-GT as substrate and [33P]ATP after 40 mins by beta counting
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor TYRO3 (CHEMBL5314) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazine-based Syk kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.86 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018145 | — | — | 1 | 7.70 |
| CHEMBL2018146 | — | — | 1 | 7.70 |
| CHEMBL2018015 | — | — | 1 | 7.55 |
| CHEMBL2018025 | — | — | 1 | 7.52 |
| CHEMBL2018023 | — | — | 1 | 7.52 |
| CHEMBL2018014 | — | — | 1 | 7.47 |
| CHEMBL2018027 | — | — | 1 | 7.40 |
| CHEMBL2018022 | — | — | 1 | 7.40 |
| CHEMBL2018028 | — | — | 1 | 7.40 |
| CHEMBL2018032 | — | — | 1 | 7.40 |
| CHEMBL2018013 | — | — | 1 | 7.38 |
| CHEMBL2018026 | — | — | 1 | 7.30 |
| CHEMBL2018024 | — | — | 1 | 7.30 |
| CHEMBL2018020 | — | — | 1 | 7.30 |
| CHEMBL2018029 | — | — | 1 | 7.22 |
| CHEMBL2018031 | — | — | 1 | 7.22 |
| CHEMBL2018147 | — | — | 1 | 7.22 |
| CHEMBL2018010 | — | — | 1 | 7.22 |
| CHEMBL2018143 | — | — | 1 | 7.22 |
| CHEMBL2018016 | — | — | 1 | 7.17 |
| CHEMBL2018030 | — | — | 1 | 7.10 |
| CHEMBL2018012 | — | — | 1 | 7.07 |
| CHEMBL2018018 | — | — | 1 | 7.00 |
| CHEMBL2018011 | — | — | 1 | 7.00 |
| CHEMBL2018019 | — | — | 1 | 6.96 |
| CHEMBL2018002 | — | — | 1 | 6.92 |
| CHEMBL2018144 | — | — | 1 | 6.75 |
| CHEMBL2018021 | — | — | 1 | 6.47 |
| CHEMBL2018009 | — | — | 1 | 6.47 |
| CHEMBL2018005 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018145 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2018146 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2018015 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2018025 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2018023 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2018014 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2018032 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2018028 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2018027 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2018022 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2018013 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2018024 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2018020 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2018026 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2018143 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2018029 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2018010 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2018147 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2018031 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2018016 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2018030 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2018012 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2018011 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2018018 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2018019 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2018002 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2018144 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2018021 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2018009 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2018005 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2018001 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2018017 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2018006 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2018008 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2018004 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2017998 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2017999 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2018000 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2017997 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2018003 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2018148 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2018007 | — | IC50 | > | 50000.0 | nM | - |