Assay Detail
Binding
CHEMBL2019837
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Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 12 hrs by stopped flow CO2 hydration assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.44 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 5.73 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 5.46 |
| CHEMBL294009 | FLAVONOL | — | 1 | 5.29 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275638 | FLAVONE | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Ki | = | 3430.0 | nM | 5.46 |
| CHEMBL294009 | FLAVONOL | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL117 | CHRYSIN | Ki | = | 5420.0 | nM | 5.27 |