Assay Detail
Binding
CHEMBL2019848
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Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.11 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2019143 | — | — | 1 | 5.17 |
| CHEMBL2019140 | — | — | 1 | 5.10 |
| CHEMBL2019155 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2019143 | — | Ki | = | 6750.0 | nM | 5.17 |
| CHEMBL2019140 | — | Ki | = | 7950.0 | nM | 5.10 |
| CHEMBL2019155 | — | Ki | = | 8980.0 | nM | 5.05 |