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Assay Detail

CHEMBL2020222

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of His-tagged recombinant Trypanosoma brucei fructose bis-phosphate aldolase expressed in Escherichia coli using FBP as substrate after 5 to 15 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma brucei brucei
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fructose-bisphosphate aldolase, glycosomal (CHEMBL4916)
Type SINGLE PROTEIN
Organism Trypanosoma brucei brucei

Publication

Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases.
Mabiala-Bassiloua CG, Arthus-Cartier G, Hannaert V, Thérisod H, Sygusch J, Thérisod M.
ACS Med Chem Lett (2011) 2 : 804 -808
PubMed 24900268 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.80 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2017785 1 5.70
CHEMBL258208 1 5.03
CHEMBL1235112 1 5.00
CHEMBL2017790 1 4.82
CHEMBL2017788 1 4.51
CHEMBL2017786 1 4.29
CHEMBL2017791 1 4.25
CHEMBL2017787 1 -
CHEMBL2017789 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2017785 IC50 = 2000.0 nM 5.70
CHEMBL258208 IC50 = 9400.0 nM 5.03
CHEMBL1235112 IC50 = 10000.0 nM 5.00
CHEMBL2017790 IC50 = 15000.0 nM 4.82
CHEMBL2017788 IC50 = 31000.0 nM 4.51
CHEMBL2017786 IC50 = 51000.0 nM 4.29
CHEMBL2017791 IC50 = 56000.0 nM 4.25
CHEMBL2017787 IC50 = 117000.0 nM -
CHEMBL2017789 IC50 = 130000.0 nM -