Assay Detail
Binding
CHEMBL2020223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit muscle FBA assessed as inhibition of FBP cleavage by spectrophotometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fructose-bisphosphate aldolase A (CHEMBL4695) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.79 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017785 | — | — | 1 | 5.12 |
| CHEMBL258208 | — | — | 1 | 5.10 |
| CHEMBL1235112 | — | — | 1 | 4.89 |
| CHEMBL2017790 | — | — | 1 | 4.77 |
| CHEMBL2017788 | — | — | 1 | 4.68 |
| CHEMBL2017786 | — | — | 1 | 4.19 |
| CHEMBL2017787 | — | — | 1 | - |
| CHEMBL2017789 | — | — | 1 | - |
| CHEMBL2017791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017785 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL258208 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1235112 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2017790 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2017788 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2017786 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL2017787 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL2017789 | — | IC50 | = | 244000.0 | nM | - |
| CHEMBL2017791 | — | IC50 | = | 137000.0 | nM | - |