Assay Detail
Binding
CHEMBL2020291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleotide-binding oligomerization domain-containing protein 2 (CHEMBL1293266) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 5.70 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1713298 | — | — | 1 | 7.52 |
| CHEMBL1732337 | — | — | 1 | 6.70 |
| CHEMBL1704728 | — | — | 1 | 6.58 |
| CHEMBL1450407 | — | — | 1 | 6.41 |
| CHEMBL1569174 | — | — | 1 | 6.40 |
| CHEMBL1569954 | — | — | 1 | 6.24 |
| CHEMBL1709705 | — | — | 1 | 6.22 |
| CHEMBL1700405 | — | — | 1 | 6.11 |
| CHEMBL1735926 | — | — | 1 | 5.85 |
| CHEMBL1364793 | — | — | 1 | 5.81 |
| CHEMBL1721926 | — | — | 1 | 5.80 |
| CHEMBL1710033 | — | — | 1 | 5.79 |
| CHEMBL1720257 | — | — | 1 | 5.76 |
| CHEMBL1532328 | — | — | 1 | 5.73 |
| CHEMBL1717116 | — | — | 1 | 5.48 |
| CHEMBL1733280 | — | — | 1 | 5.46 |
| CHEMBL1734509 | — | — | 1 | 5.45 |
| CHEMBL1612423 | — | — | 1 | 5.45 |
| CHEMBL1351584 | — | — | 1 | 5.44 |
| CHEMBL1420187 | — | — | 1 | 5.43 |
| CHEMBL1554526 | — | — | 1 | 5.42 |
| CHEMBL1538784 | — | — | 1 | 5.10 |
| CHEMBL1700889 | — | — | 1 | 5.08 |
| CHEMBL1717353 | — | — | 1 | 5.07 |
| CHEMBL1706268 | — | — | 1 | 5.03 |
| CHEMBL1314048 | — | — | 1 | 4.92 |
| CHEMBL1712058 | — | — | 1 | 4.76 |
| CHEMBL1521474 | — | — | 1 | 4.70 |
| CHEMBL1728008 | — | — | 1 | - |
| CHEMBL1710228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1713298 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1732337 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1704728 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1450407 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1569174 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1569954 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1709705 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1700405 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1735926 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL1364793 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL1721926 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL1710033 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL1720257 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1532328 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL1717116 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL1733280 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1734509 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL1612423 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL1351584 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL1420187 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL1554526 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1538784 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1700889 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL1717353 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL1706268 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL1314048 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1712058 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL1521474 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL1732890 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1706542 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1725712 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1699379 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1342760 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1433326 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2018276 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1535050 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1363341 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2018275 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1411903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1519988 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1321508 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1407805 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1316316 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1412853 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1719579 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1720861 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1736791 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1729147 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1710228 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1728008 | — | IC50 | > | 20000.0 | nM | - |