Assay Detail
Binding
CHEMBL2020482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mouse brain mu opioid receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.60 | 10.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016678 | — | — | 1 | 10.31 |
| CHEMBL2016675 | — | — | 1 | 10.01 |
| CHEMBL2016679 | — | — | 1 | 9.57 |
| CHEMBL2016673 | — | — | 1 | 9.55 |
| CHEMBL2016674 | — | — | 1 | 9.55 |
| CHEMBL2016672 | — | — | 1 | 9.39 |
| CHEMBL2016677 | — | — | 1 | 9.35 |
| CHEMBL2016676 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016678 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL2016675 | — | Ki | = | 0.097 | nM | 10.01 |
| CHEMBL2016679 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL2016673 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL2016674 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL2016672 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL2016677 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL2016676 | — | Ki | = | 0.9 | nM | 9.05 |