Assay Detail
Binding
CHEMBL2020483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPDPE from kappa opioid receptor in guinea pig cerebellum membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.18 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016678 | — | — | 1 | 9.72 |
| CHEMBL2016675 | — | — | 1 | 9.54 |
| CHEMBL2016676 | — | — | 1 | 9.47 |
| CHEMBL2016679 | — | — | 1 | 9.46 |
| CHEMBL2016672 | — | — | 1 | 9.33 |
| CHEMBL2016673 | — | — | 1 | 9.07 |
| CHEMBL2016674 | — | — | 1 | 8.85 |
| CHEMBL2016677 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016678 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL2016675 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2016676 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL2016679 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL2016672 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL2016673 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL2016674 | — | Ki | = | 1.42 | nM | 8.85 |
| CHEMBL2016677 | — | Ki | = | 9.91 | nM | 8.00 |