Assay Detail
Binding
CHEMBL2020484
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Displacement of [3H]U-69,593 from mouse brain delta opioid receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.30 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016678 | — | — | 1 | 9.13 |
| CHEMBL2016675 | — | — | 1 | 8.64 |
| CHEMBL2016679 | — | — | 1 | 8.60 |
| CHEMBL2016674 | — | — | 1 | 8.21 |
| CHEMBL2016672 | — | — | 1 | 8.03 |
| CHEMBL2016676 | — | — | 1 | 8.00 |
| CHEMBL2016677 | — | — | 1 | 7.92 |
| CHEMBL2016673 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016678 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL2016675 | — | Ki | = | 2.28 | nM | 8.64 |
| CHEMBL2016679 | — | Ki | = | 2.49 | nM | 8.60 |
| CHEMBL2016674 | — | Ki | = | 6.12 | nM | 8.21 |
| CHEMBL2016672 | — | Ki | = | 9.39 | nM | 8.03 |
| CHEMBL2016676 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL2016677 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL2016673 | — | Ki | = | 13.5 | nM | 7.87 |