Assay Detail
Binding
CHEMBL2020637
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Inhibition of beta-casein/TCF4 pathway expressed in HCT116 cells containing delta45S mutant after 24 hrs by luciferase reporter gene assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HCT-116 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.61 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018626 | — | — | 1 | 6.00 |
| CHEMBL2018615 | — | — | 1 | 5.82 |
| CHEMBL2018726 | — | — | 1 | 5.82 |
| CHEMBL2018727 | — | — | 1 | 5.70 |
| CHEMBL2018623 | — | — | 1 | 5.70 |
| CHEMBL2018734 | — | — | 1 | 5.60 |
| CHEMBL2018597 | — | — | 1 | 5.60 |
| CHEMBL2018621 | — | — | 1 | 5.60 |
| CHEMBL2018622 | — | — | 1 | 5.60 |
| CHEMBL2018733 | — | — | 1 | 5.52 |
| CHEMBL2018617 | — | — | 1 | 5.52 |
| CHEMBL2018598 | — | — | 1 | 5.52 |
| CHEMBL2018728 | — | — | 1 | 5.52 |
| CHEMBL2018732 | — | — | 1 | 5.52 |
| CHEMBL2018614 | — | — | 1 | 5.52 |
| CHEMBL569102 | — | — | 1 | 5.46 |
| CHEMBL2018729 | — | — | 1 | 5.46 |
| CHEMBL2018612 | — | — | 1 | 5.46 |
| CHEMBL2018618 | — | — | 1 | - |
| CHEMBL2018735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018626 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2018615 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2018726 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2018727 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2018623 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2018734 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2018597 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2018621 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2018622 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2018733 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2018617 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2018598 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2018728 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2018732 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2018614 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL569102 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2018729 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2018612 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2018618 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2018735 | — | IC50 | > | 5000.0 | nM | - |