Compound Detail
CHEMBL569102
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Basic Information
| ChEMBL ID | CHEMBL569102 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WWBNWNFPDKAYDJ-UHFFFAOYSA-N |
4
Targets
7
Activities
1
Assay Types
1
PK Parameters
8
Publications
0
Known Names
Molecular Properties
401.4
MW (Da)
4.68
ALogP
5
HBA
3
HBD
78.9
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 6.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TCF4/beta-catenin CHEMBL3038511 | IC50 | 6.38 | 6.07 | 413.0 | 3 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 6.38 | 6.375 | 413.0 | 2 |
| HCT-116 CHEMBL394 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| SW480 CHEMBL612544 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.35 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 413.0 | nM | 6.38 | Growth inhibition of human Tcf 33.13 cells transiently transfected with pGL3-Tcf... | 20025292 |
| TCF4/beta-catenin | IC50 | = | 413.0 | nM | 6.38 | Inhibition of TCF-4/beta catenin in human Tcf33.13 cells expressing Tcf-4/SV40 b... | - |
| NON-PROTEIN TARGET | IC50 | = | 424.0 | nM | 6.37 | Growth inhibition of human Tcf22C11 cells transiently transfected with pGL3-Tcf4... | 20025292 |
| TCF4/beta-catenin | IC50 | = | 423.0 | nM | 6.37 | Inhibition of TCF-4/beta catenin in human Tcf22C11 cells expressing Tcf-4/SV40 b... | - |
| HCT-116 | IC50 | = | 1600.0 | nM | 5.8 | Growth inhibition of human HCT116 cells assessed as viable cells after 3 days us... | 22229647 |
| SW480 | IC50 | = | 2000.0 | nM | 5.7 | Growth inhibition of human SW480 cells assessed as viable cells after 3 days usi... | 22229647 |
| TCF4/beta-catenin | IC50 | = | 3500.0 | nM | 5.46 | Inhibition of beta-casein/TCF4 pathway expressed in HCT116 cells containing delt... | 22229647 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20025292 | 10.1021/jm901370m | NON-PROTEIN TARGET | 3 |
| 20025292 | 10.1021/jm901370m | No relevant target | 1 |
| 20025292 | 10.1021/jm901370m | Liver microsomes | 1 |
| 20025292 | 10.1021/jm901370m | ADMET | 1 |
| 22229647 | 10.1021/jm201494a | TCF4/beta-catenin | 1 |
| 22229647 | 10.1021/jm201494a | HCT-116 | 1 |
| 22229647 | 10.1021/jm201494a | SW480 | 1 |
| 22229647 | 10.1021/jm201494a | Molecular identity unknown | 1 |
Data from ChEMBL 36 via Core Engine