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Assay Detail

CHEMBL3883064

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TCF-4/beta catenin in human Tcf22C11 cells expressing Tcf-4/SV40 binding sites driving firefly luciferase reporter gene after 24 hrs by luminometer
ChEMBL ↗
264
Total Activities
264
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Tcf22C11
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

TCF4/beta-catenin (CHEMBL3038511) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Amino-substituted quinazoline derivatives as inhibitors of Beta-catenin/TCF-4 pathway and cancer treatment agents
(2009)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 264 6.00 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3934717 — — 1 7.00
CHEMBL568799 — — 1 6.83
CHEMBL3955823 — — 1 6.78
CHEMBL3897759 — — 1 6.71
CHEMBL3959525 — — 1 6.69
CHEMBL3958263 — — 1 6.67
CHEMBL3935110 — — 1 6.67
CHEMBL3983546 — — 1 6.67
CHEMBL3939175 — — 1 6.65
CHEMBL3895814 — — 1 6.65
CHEMBL3970316 — — 1 6.64
CHEMBL3953013 — — 1 6.64
CHEMBL3963724 — — 1 6.62
CHEMBL3940417 — — 1 6.60
CHEMBL566677 — — 1 6.58
CHEMBL3931303 — — 1 6.58
CHEMBL3965907 — — 1 6.57
CHEMBL570194 — — 1 6.56
CHEMBL3897769 — — 1 6.55
CHEMBL3981410 — — 1 6.50
CHEMBL583050 — — 1 6.48
CHEMBL3930638 — — 1 6.46
CHEMBL566888 — — 1 6.46
CHEMBL565824 — — 1 6.43
CHEMBL569230 — — 1 6.42
CHEMBL3927222 — — 1 6.42
CHEMBL577512 — — 1 6.41
CHEMBL566462 — — 1 6.41
CHEMBL3896117 — — 1 6.40
CHEMBL569962 — — 1 6.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3934717 — IC50 = 100.0 nM 7.00
CHEMBL568799 — IC50 = 148.0 nM 6.83
CHEMBL3955823 — IC50 = 168.0 nM 6.78
CHEMBL3897759 — IC50 = 196.0 nM 6.71
CHEMBL3959525 — IC50 = 204.0 nM 6.69
CHEMBL3958263 — IC50 = 215.0 nM 6.67
CHEMBL3983546 — IC50 = 215.0 nM 6.67
CHEMBL3935110 — IC50 = 213.0 nM 6.67
CHEMBL3939175 — IC50 = 223.0 nM 6.65
CHEMBL3895814 — IC50 = 223.0 nM 6.65
CHEMBL3953013 — IC50 = 229.0 nM 6.64
CHEMBL3970316 — IC50 = 229.0 nM 6.64
CHEMBL3963724 — IC50 = 238.0 nM 6.62
CHEMBL3940417 — IC50 = 249.0 nM 6.60
CHEMBL3931303 — IC50 = 266.0 nM 6.58
CHEMBL566677 — IC50 = 262.0 nM 6.58
CHEMBL3965907 — IC50 = 268.0 nM 6.57
CHEMBL570194 — IC50 = 273.0 nM 6.56
CHEMBL3897769 — IC50 = 284.0 nM 6.55
CHEMBL3981410 — IC50 = 318.0 nM 6.50
CHEMBL583050 — IC50 = 329.0 nM 6.48
CHEMBL3930638 — IC50 = 346.0 nM 6.46
CHEMBL566888 — IC50 = 347.0 nM 6.46
CHEMBL565824 — IC50 = 373.0 nM 6.43
CHEMBL569230 — IC50 = 382.0 nM 6.42
CHEMBL3927222 — IC50 = 376.0 nM 6.42
CHEMBL577512 — IC50 = 389.0 nM 6.41
CHEMBL566462 — IC50 = 390.0 nM 6.41
CHEMBL3896117 — IC50 = 397.0 nM 6.40
CHEMBL3970869 — IC50 = 408.0 nM 6.39
CHEMBL569962 — IC50 = 405.0 nM 6.39
CHEMBL3941310 — IC50 = 414.0 nM 6.38
CHEMBL3972044 — IC50 = 422.0 nM 6.38
CHEMBL3923806 — IC50 = 429.0 nM 6.37
CHEMBL569102 — IC50 = 423.0 nM 6.37
CHEMBL3953370 — IC50 = 428.0 nM 6.37
CHEMBL569231 — IC50 = 431.0 nM 6.37
CHEMBL3906097 — IC50 = 439.0 nM 6.36
CHEMBL3978183 — IC50 = 437.0 nM 6.36
CHEMBL3921998 — IC50 = 434.0 nM 6.36
CHEMBL3924699 — IC50 = 436.0 nM 6.36
CHEMBL3891176 — IC50 = 451.0 nM 6.35
CHEMBL3897819 — IC50 = 452.0 nM 6.34
CHEMBL3895823 — IC50 = 462.0 nM 6.33
CHEMBL3942535 — IC50 = 464.0 nM 6.33
CHEMBL3931398 — IC50 = 462.0 nM 6.33
CHEMBL3913906 — IC50 = 478.0 nM 6.32
CHEMBL3961169 — IC50 = 494.0 nM 6.31
CHEMBL3917441 — IC50 = 497.0 nM 6.30
CHEMBL569004 — IC50 = 505.0 nM 6.30