Assay Detail
Functional
CHEMBL1047013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human Tcf22C11 cells transiently transfected with pGL3-Tcf4-luc and SV40-R-luc after 24 hrs by luciferase reporter assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Tcf22C11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.07 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583050 | — | — | 1 | 6.48 |
| CHEMBL569230 | — | — | 1 | 6.47 |
| CHEMBL569321 | — | — | 1 | 6.46 |
| CHEMBL570194 | — | — | 1 | 6.43 |
| CHEMBL577512 | — | — | 1 | 6.41 |
| CHEMBL569962 | — | — | 1 | 6.39 |
| CHEMBL569231 | — | — | 1 | 6.37 |
| CHEMBL569102 | — | — | 1 | 6.37 |
| CHEMBL568799 | — | — | 1 | 6.33 |
| CHEMBL569004 | — | — | 1 | 6.30 |
| CHEMBL568800 | — | — | 1 | 6.28 |
| CHEMBL569919 | — | — | 1 | 6.25 |
| CHEMBL577072 | — | — | 1 | 6.24 |
| CHEMBL568851 | — | — | 1 | 6.23 |
| CHEMBL568852 | — | — | 1 | 6.21 |
| CHEMBL570902 | — | — | 1 | 6.19 |
| CHEMBL583242 | — | — | 1 | 6.19 |
| CHEMBL569745 | — | — | 1 | 6.18 |
| CHEMBL569077 | — | — | 1 | 6.18 |
| CHEMBL569103 | — | — | 1 | 6.16 |
| CHEMBL569098 | — | — | 1 | 6.09 |
| CHEMBL569532 | — | — | 1 | 6.08 |
| CHEMBL568853 | — | — | 1 | 6.08 |
| CHEMBL569533 | — | — | 1 | 6.07 |
| CHEMBL583544 | — | — | 1 | 6.05 |
| CHEMBL569754 | — | — | 1 | 6.03 |
| CHEMBL568825 | — | — | 1 | 6.00 |
| CHEMBL569099 | — | — | 1 | 5.98 |
| CHEMBL570656 | — | — | 1 | 5.95 |
| CHEMBL570417 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583050 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL569230 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL569321 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL570194 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL577512 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL569962 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL569231 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL569102 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL568799 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL569004 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL568800 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL569919 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL577072 | — | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL568851 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL568852 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL570902 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL583242 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL569745 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL569077 | — | IC50 | = | 659.0 | nM | 6.18 |
| CHEMBL569103 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL569098 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL568853 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL569532 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL569533 | — | IC50 | = | 848.0 | nM | 6.07 |
| CHEMBL583544 | — | IC50 | = | 895.0 | nM | 6.05 |
| CHEMBL569754 | — | IC50 | = | 931.0 | nM | 6.03 |
| CHEMBL568825 | — | IC50 | = | 1008.0 | nM | 6.00 |
| CHEMBL569099 | — | IC50 | = | 1046.0 | nM | 5.98 |
| CHEMBL570656 | — | IC50 | = | 1113.0 | nM | 5.95 |
| CHEMBL570417 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL571994 | — | IC50 | = | 1188.0 | nM | 5.92 |
| CHEMBL584735 | — | IC50 | = | 1716.0 | nM | 5.76 |
| CHEMBL569002 | — | IC50 | = | 1779.0 | nM | 5.75 |
| CHEMBL585143 | — | IC50 | = | 2012.0 | nM | 5.70 |
| CHEMBL583471 | — | IC50 | = | 2138.0 | nM | 5.67 |
| CHEMBL570418 | — | IC50 | = | 2274.0 | nM | 5.64 |
| CHEMBL568821 | — | IC50 | = | 2592.0 | nM | 5.59 |
| CHEMBL576864 | — | IC50 | = | 5642.0 | nM | 5.25 |
| CHEMBL569682 | — | IC50 | = | 6814.0 | nM | 5.17 |
| CHEMBL568823 | — | IC50 | > | 25158.0 | nM | - |
| CHEMBL582809 | — | IC50 | > | 2720.0 | nM | - |