Compound Detail

CHEMBL568821

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CC(=O)c1ccc2c(NCc3ccc(NC(=O)c4ccc(F)cc4)cc3)nc(N(C)C)nc2c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL568821
Phase	Preclinical
Structure Type	MOL
InChI Key	KGVIKCUJOCKZNT-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

457.5

MW (Da)

4.90

ALogP

HBA

HBD

87.2

PSA (Å²)

0.38

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 4 meas. best 5.63

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
TCF4/beta-catenin CHEMBL3038511	IC50	5.63	5.61	2331.0	2
NON-PROTEIN TARGET CHEMBL3879801	IC50	5.63	5.61	2330.0	2

Parameter	Value	Units	Species
T1/2	0.03333	hr	Rattus norvegicus

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
NON-PROTEIN TARGET	IC50	=	2330.0	nM	5.63	Growth inhibition of human Tcf 33.13 cells transiently transfected with pGL3-Tcf...	20025292
TCF4/beta-catenin	IC50	=	2331.0	nM	5.63	Inhibition of TCF-4/beta catenin in human Tcf33.13 cells expressing Tcf-4/SV40 b...	-
NON-PROTEIN TARGET	IC50	=	2592.0	nM	5.59	Growth inhibition of human Tcf22C11 cells transiently transfected with pGL3-Tcf4...	20025292
TCF4/beta-catenin	IC50	=	2592.0	nM	5.59	Inhibition of TCF-4/beta catenin in human Tcf22C11 cells expressing Tcf-4/SV40 b...	-

PubMed	DOI	Target Context	# Activities
20025292	10.1021/jm901370m	NON-PROTEIN TARGET	3
20025292	10.1021/jm901370m	No relevant target	1
20025292	10.1021/jm901370m	Liver microsomes	1
20025292	10.1021/jm901370m	ADMET	1

Data from ChEMBL 36 via Core Engine