Assay Detail
Binding
CHEMBL2020707
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Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate preincubated for 15 mins prior substrate addition measured after 15 mins by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new pancreatic lipase inhibitor from Broussonetia kanzinoki.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.65 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 6.52 |
| CHEMBL2017114 | BROUSSONONE A | — | 1 | 4.55 |
| CHEMBL463454 | BROUSSONIN B | — | 1 | 4.12 |
| CHEMBL508033 | — | — | 1 | 4.07 |
| CHEMBL465879 | BROUSSONIN A | — | 1 | 4.01 |
| CHEMBL2017115 | — | — | 1 | - |
| CHEMBL2017116 | — | — | 1 | - |
| CHEMBL2017117 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2017114 | BROUSSONONE A | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL463454 | BROUSSONIN B | IC50 | = | 75400.0 | nM | 4.12 |
| CHEMBL508033 | — | IC50 | = | 85100.0 | nM | 4.07 |
| CHEMBL465879 | BROUSSONIN A | IC50 | = | 98700.0 | nM | 4.01 |
| CHEMBL2017115 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017116 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017117 | — | IC50 | > | 100000.0 | nM | - |